As you say a prayer for all the folks on the Gulf coast, don't forget South Florida. They took a massive hit as well while the Katrina was still "just" a Category 1.
This looks to be a disaster of epic proportions. New Orleans - under water, Gulfport - destroyed, Biloxi - destroyed, Mobile - flooding. Interstate bridges out. No water, no communications. Stories of people losing loved ones, floating away. My wife had tears rolling down her face as we watched the news last night.